- Increases emotional openness and clarity
- Enhances neuroplasticity
- Supports breakthrough insights
- Promotes long-term growth through integration
- Reduces depression, anxiety, and PTSD symptoms
- Individuals experiencing moderate to severe depression
- People living with treatment-resistant depression who haven’t found relief with traditional approaches
- Those struggling with anxiety, generalized worry, or panic
- Individuals dealing with PTSD or the lingering effects of traumatic experiences
- People experiencing emotional rigidity, rumination, or feeling “stuck” in old patterns
- Clients looking to enhance psychological flexibility and increase openness to therapeutic change
- Individuals navigating major life transitions, grief, or burnout
- People who benefit from experiential or insight-based therapy approaches
- Clients seeking a structured, medically supported alternative to medication alone
- Those interested in pairing ketamine with psychotherapy for deeper healing and integration
Psychedelics increase psychological flexibility, helping people adapt, shift perspective, and regulate emotions (Sakopoulos & Todman, 2025).
This is important because psychological flexibility is a key predictor of mental health and receptiveness to new ideas (Constantinou et al., 2021).
Psychedelics can quiet the Default Mode Network (DMN), which reduces rumination.
Neuroimaging research demonstrates that psychedelic medicines like ketamine decrease activity in the DMN, which is associated with overthinking, self-criticism, and depressive loops (Scheidegger et al., 2012).
PAT is clinically distinct from recreational psychedelic use.
Clinical PAT involves controlled dosing, medical monitoring, and structured psychotherapy, leading to safer and more reliable outcomes.
PAT promotes rapid neuroplasticity, which helps the brain form new, healthier pathways that support mood regulation and emotional flexibility.
The medicine enhances synaptogenesis and strengthens neural circuits in brain regions involved in mood regulation (Marguilho et al., 2022).
PAT works best when combined with integrative psychotherapy.
Research suggests that integration enhances the effectiveness of therapeutic interventions (Sakopoulos & Todman, 2025).